Efficient Synthesis of the C1- C7 Fragment of Didemnaketal A

The stereoselective synthesis of the C1-C7 fragment (3R,4S,6R)-3,4-di[(tert-butyl- dimethylsilyl)oxy]-7-hydroxy-6-methylheptan-2-one, which is the crucial intermediate for synthesis of the HIV-1 protease inhibitive didemnaketals, was developed via 12 steps from the natural (+)-pulegone.

作 者： Xue Qiang LI Xue Zhi ZHAO Pei Nian LIU Yong Qiang TU   作者單位： Xue Qiang LI(Department of Chemistry and State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000;Department of Chemistry,Ningxia University,Yinchuan 750021)

Xue Zhi ZHAO,Pei Nian LIU,Yong Qiang TU(Department of Chemistry and State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000) 

刊 名： 中國化學(xué)快報(英文版)  ISTIC SCI 英文刊名： CHINESE CHEMICAL LETTERS  年，卷(期)： 2004 15(7)  分類號：   關(guān)鍵詞： Didemnaketals   stereoselective synthesis   intramolecular chiral induction   Mitsunobu reaction  

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